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The TSC Alliance was founded by four mothers in Southern California in 1974 and incorporated in the state of California on March 15, 1975 as the National Tuberous Sclerosis Association.  We remain a California corporation, the National Tuberous Sclerosis Association, doing business as the TSC Alliance.

The TSC Alliance Endowment Fund was founded after the TSC Alliance had moved its headquarters just outside of Washington, DC.  It was incorporated in the state of Maryland on April 3, 1995.