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Kidney (renal) manifestations such as cystic disease and renal angiomyolipomas continue to grow throughout this part of the lifespan. Not only is your loved one aging, in which chronic kidney disease tends to manifest in general adulthood, but the progression of TSC-specific manifestations and long-term medication use all contribute to factors that place your loved one at risk for chronic kidney disease and/or hypertension. Surveillance with MRI of the abdomen is still recommended every 1 to 3 years during this timeframe. Ideal diet, daily exercise and maintaining an optimal blood pressure are essential for not only general and cardiovascular health purposes but also to minimize declining renal function.